磷脂酰肌醇蛋白聚糖3对原发性肝细胞癌的诊断价值评价-现代医学

磷脂酰肌醇蛋白聚糖3对原发性肝细胞癌的诊断价值评价

作者：刘阳

单位：武警湖南总队医院

分类号：

出版年·卷·期（页码）：2014··第二期（0-）

摘要：

摘要：【目的】探讨血清磷脂酰肌醇蛋白聚糖3（GPC3）对原发性肝细胞癌的诊断价值。【方法】应用酶联免疫法测定35例肝细胞癌、26例肝硬化和50例健康人血清GPC3和甲胎蛋白（AFP）水平。【结果】肝细胞癌组、肝硬化组和健康对照组血清GPC3分别为4.16±2.35 ng/ml，3.13±1.19 ng/ml，1.92±1.23ng/ml，肝细胞癌组明显高于肝硬化组和健康对照组，差异有统计学意义。对于诊断肝细胞癌，GPC3的ROC曲线下面积为0.789，AFP为0.803；GPC3敏感性82.8%，特异性56.5%， AFP敏感性62.8%，特异性78.9%。联合应用GPC3与AFP诊断HCC，敏感性为91.4%，特异性为45.6%。对于Ⅰ+Ⅱ期肝细胞癌，GPC3（11/14）的阳性率高于AFP（4/14），差异有统计学意义。【结论】GPC3是一个敏感且特异的肝细胞癌标志物，检测血清GPC3有助于肝细胞癌的诊断与研究。

【Objective】To evaluate the diagnostic value of serum glypican-3(GPC3) for primary hepatocellular carcinoma(HCC).【Methods】Serum levels of GPC3 and α-fetoprotein(AFP) were measured in 35 HCC, 32 liver cirrhosis patients and 50 health by ELISA method.【Results】The serum GPC3 levels were 4.16±2.35 ng/ml，3.13±1.19 ng/ml，1.92±1.23ng/ml in HCC, liver cirrhorsis group and health group respectively, and there was a significant diffrence between HCC group and the other two groups.The area under the ROC curve of GPC3 was 0.789 while AFP was 0.803; the GPC3`s sensitivity and specificity for HCC were 82.8% and 56.5%, while AFP were 62.8% and 78.9%. when combined GPC3 and AFP, the sensitivity and specificity were 91.4% and 45.6%.GPC3`s positive incidence(11/14) was higher than AFP`s(4/14) in Ⅰ+Ⅱ grade HCC group. 【Conclusion】The GPC3 protein is a sensitive and specific serum marker for diagnosis of HCC, and it may provide a novel diagnosis and research tool for HCC.

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