【Abstract】Objective: Discuss the high quality nursing service mode emergency poisoning patients with craniocerebral injury the application and effect.Methods: According to the time 100 patients with emergency severe craniocerebral injury patients were divided into control group and treatment group the fifty cases and control according to the emergency severe craniocerebral injury first aid conventional first aid care, treatment group in the control group implementation based on high quality nursing service mode, observation compared between the two groups of patients with rescue success rate and mortality of the patients, and the disposal of the speed, the patient and family to nursing job satisfaction. Experimental: Treatment group patients rescue success rate higher than that of the control group, the death rate is lower than control group, and the disposal of the patients with faster than the control group, patients and their families in the nursing job satisfaction is better than the control group, Between the two groups have significant difference (P<0.05).Conclusion: High quality nursing service mode applied in emergency poisoning patients with craniocerebral injury patients with first aid for rescue win gold time, effectively improve the patient's rescue success rate and reduce the mortality rate of patients and improve the patients and their families in the nursing job satisfaction.