【 abstract 】Objective: To investigate the efficacy and safety of dezocine combined with tramadol to postoperative pain in the analepsia stage of general anesthesia. Methods: 120 inpatients of our hospital from January 2012 to December 2012 undergoing open abdominal surgery were randomly divided into 3 groups, dezocine group (group D), sufentanil group (group S), and dezocine + tramadol group (group DQ), 40 cases in each group. 30 minutes before the end of the operation, patients in group D were intravenous injected dezocine 0.1 mg / kg; patients in group S were intravenous injected sufentanil 0.1μg / KG, and patients in group DQ were intramuscular injected dezocine 0.1 mg / kg + tramadol 2mg/kg. we observed the spontaneous breathing recovery time, palinesthesia time and extubation time, postanesthesia care unit (PACU) stay time; Awakening period pain (VAS) score, calm, agitated (SAS) score and comfort (BCS) score, and recorded the respiratory depression, drowsiness, dizziness, nausea, vomiting and other adverse reactions of patients in the 3 groups. Results: Spontaneous breathing recovery time, palinesthesia time, extubation time are longer in group S, but compare with other groups, the differences have no statistically significant.(P> 0.05); PACU stay time is longer in group S, the difference has statistically significant (P <0.05); compare the VAS, SAS, BCS scores in 3 groups after palinesthesia, the VAS and SAS are lower in group S and group DQ than in the group D, and the differences have statistically significant (P <0.05); BCS score is higher in group S and group DQ than that in group D, the differences have statistically significant (P <0.05). The incidence of adverse reactions of group DQ is lower than that in other 2 groups. Conclusions: the 3 modes of administration are all can effectively alleviate the acute pain in the analepsia stage of general anesthesia. Intramuscular injection of dezocine combined with tramadol with longer action time, shorter P