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阻塞性睡眠呼吸暂停低通气综合征患者血清瘦素与白细胞介素6的关系研究
作者:李春华 朱述阳 李家树  
单位:连云港市第一人民医院
关键词:阻塞性睡眠呼吸暂停低通气综合征 肥胖 瘦素 白细胞介素6 
分类号:
出版年·卷·期(页码):2013·41·第十二期(881-885)
摘要:

[摘要]目的:探讨阻塞性睡眠呼吸暂停低通气综合征患者血清瘦素及白细胞介素6(IL-6)的变化及其临床意义。方法:选择27例阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者和28例对照组健康人,通过多导睡眠呼吸监测仪(PSG)监测整夜7小时以上睡眠过程,次日清晨抽取静脉血使用放射免疫法测血清瘦素、IL-6水平。结果:(1)OSAHS组患者血清瘦素水平显著高于对照组(P<0.01);(2)OSAHS组患者血清IL-6水平显著高于对照组(P<0.01);(3)OSAHS组患者血清瘦素水平与BMI(r=0.915, P<0.01)、颈围(r=0.907, P<0.01)、AHI(r=0.398, P<0.05)呈正相关、而与最低Sa02(r=0.-275, P>0.05)无关;OSAHS组患者血清IL-6水平与BMI(r=0.633, P<0.01)、颈围(r=0.682, P<0.01)、AHI(r=0.693, P<0.01)呈正相关、而与最低Sa02呈负相关(r=-0.683, P<0.01);(4)OSAHS组患者血清瘦素水平与IL-6(r=0.690, P<0.01)呈正相关。结论:(1)OASHS患者血清瘦素与IL-6水平均比正常人升高,并且与病情严重程度有关。(2)OASHS患者血清瘦素可能与IL-6有关。

Abstract:【Objective】To explore the changes of leptin and interleukin-6(IL-6) levels as well as its meaning in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).【Methods】To choose 27 patients with OSAHS as the observed group(OSAHS group), 28 obesity patients as the control group. To monitor the process of seven-hour-sleeping by Polysomnography(PSG) and venous blood was drawn for measuring the serum leptin and IL-6 level with radioimmunoassay the next morning. 【Results】 (1)The leptin level of the OSAHS group was significantly higher than that of the control group(P<0.01); (2)The IL-6 level of the OSAHS group was significantly higher than that of the control group(P<0.01); (3) The leptin level of the OSAHS group was positively related to BMI(r=0.915, P<0.01) and neck circumference(r=0.907, P<0.01), AHI(r=0.398, P<0.05), but had nothing to do with the lowest SaO2 ; The IL-6 level of the OSAHS group was positively related to BMI(r=0.633, P<0.01) and neck circumference(r=0.682, P<0.01), AHI(r=0.693, P<0.01), negatively related to the lowest SaO2 (r=-0. 683, P<0.01); (4) The leptin level of the OSAHS group was positively related to that of the IL-6(r=0.690, P<0.01). 【Conclusion】(1) Both the leptin and IL-6 level of the patients with OSHAS were not only higher than those of the healthy people, but also related to their severity of disease. (2) The leptin level was possibly related to that of IL-6 of the patients with OSHAS.

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