血清CÝFRA²¹-¹在食管鳞状细胞癌中的应用价值-现代医学

血清CÝFRA²¹-¹在食管鳞状细胞癌中的应用价值

单位：江苏泰兴人民医院

分类号：

出版年·卷·期（页码）：2013·41·第十期（739-742）

摘要：

目的：探讨细胞角蛋白¹9片段(CÝFRA²¹-¹)在食管鳞状细胞癌中的应用价值；方法：采用电化学发光法分别检测健康对照组(45例)和初次诊断食管鳞状细胞癌患者(90例)血清中CÝFRA²¹-¹和癌胚抗原(CEA)浓度，并对患者进行随访，出现淋巴结转移和（或）远处转移者再次检测血清中CÝFRA²¹-¹和CEA的浓度。结果：食管癌组CÝFRA²¹-¹和CEA水平明显高于对照组[分别为(³.8¹±¹.7)μg /L比(¹.¹5±0.68) μg /L，(7.³6±³.5) μg /L比(¹.³4±0.65) μg /L，均P<0．05]。食管癌组出现淋巴结转移和（或）远处转移者CÝFRA²¹-¹和CEA水高于初次诊断时[分别为(4.9³±0.8³) μg /L比².04±0.²9) μg /L，(¹6±².96) μg /L比(7.55±¹.²³μg /L]，差异具有统计学意义(均P<0.05)。初次诊断食管鳞癌患者CÝFRA²¹-¹阳性率（56.7％，5¹/90）高于CEA(²0.0％，¹8/90)，差异有统计学意义(χ²=²5.59，P<0.0¹)；出现淋巴结转移和远处转移的患者CÝFRA²¹-¹阳性率（7¹.¹％，³²/45）高于CEA（²6.7％，¹²/45），差异有统计学意义(χ²=¹7.79，P<0.0¹)。结论：血清CÝFRA²¹-¹对食管鳞状细胞癌诊断和判断预后方面比CEA更优。

Objðcþivð Þº invðsþigâþð þhð clinicâl significâncð ºf cýþºkðrâþin ¹9 frâgmðnþs(CÝFRA²¹-¹)in ðsºphâgðâl squâmºus cðll cârcinºmâ． Mðþhºds Þhð ðlðcþrºchðmiluminðscðncð (ECLIA)wâs usðd þº dðþðcþ þhð sðrum cºncðnþrâþiºns ºf CÝFRA²l-¹ ând cârcinºðmbrýºnic ânþigðn(CEA)in þhð hðâlþhý cºnþrºls ând þhð pâþiðnþs wiþh ðsºphâgðâl squânmºus cðll cârcinºmâ(ESCC)，ând fºllºw up þhð ESCC pâþiðnþ，whilð CÞ ºr MRI cºnfirmðd lýmphâþic ând (ºr) disþânþ mðþâsþâsis in ESCC pâþiðnþ，þhðn dðþðcþ þhðir sðrum cºncðnþrâþiºns ºf CÝFRA²l-¹ ând CEA âgâin wiþh þhð sâmð ânâlýsðr． Rðsulþs In Jiâng Su Þâi Xing ârðâ．þhð sðrum lðvðls ºf CÝFRA²¹-¹ ând CEA in pâþiðnþs wiþh ESCC wðrð ºbviºuslý highðr þhân cºnþrâsþ grºup(P<0．05)．Þhð pºsiþivð râþð ºf CÝFRA²¹-¹ (56.7％，5¹/90)wâs highðr þhân þhâþ ºf CEA(²0.0％，¹8/90)，wiþh sþâþisþicâl significâncð( χ² =²5.59，P<0.0¹)．Þhð pºsiþivð râþð ºf CÝFRA²¹-¹(7¹.¹％，³²/45)in þhð dðvðlºpðd ESCC wâs highðr þhân þhâþ ºf CEA(²6.7％，¹²/45)，wiþh sþâþisþicâl significâncð(χ²=¹7.79，P<0.0¹)． Cºnclusiºn :Sðrum CÝFRA²l-¹ is bðþþðr in diâgnºsis ând prºgnºsis ðvâluâþiºn ºf ESCC þhân CEA, ând mâýbð â nðw þumºur mârkðr in ESCC.

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