血清NTx、BSP和PSA检测在前列腺癌骨转移诊断中的意义-现代医学

血清NTx、BSP和PSA检测在前列腺癌骨转移诊断中的意义

单位：东南大学医学院附属江阴医院肿瘤科

关键词：Ⅰ型胶原氨基末端肽（NTx）骨唾液酸蛋白（BSP）前列腺特异抗原（PSA）骨转移前列腺癌

分类号：

出版年·卷·期（页码）：2013·41·第八期（546-549）

摘要：

目的：探索前列腺癌患者血清中Ⅰ型胶原氨基末端肽（NTx）、骨唾液酸蛋白（BSP）以及前列腺特异抗原（PSA）的含量与骨转移发生之间的关系。方法：收集73例前列腺癌患者，其中骨转移组38例，无骨转移组35例。采用酶联免疫吸附法检测两组患者血清中的NTx、BSP和PSA的含量并进行统计分析。结果：骨转移组血清中的NTx、BSP的含量（分别为25.38±11.13 nmol/l、46.28±15.29 ng/ml）明显高于无骨转移组（分别为12.41±7.04 nmol/l、26.95±14.49 ng/ml），差异有统计学意义（P< 0.05），而骨转移组血清PSA含量（128.46±28.67 ng/ml）与无骨转移组含量（105.23±20.04 ng/ml）比较，差别无统计学意义（P >0.05）；血清NTx含量作为骨转移分子标记的灵敏度达90.0% ，特异性为68.6%；血清BSP的灵敏度为84.2%，特异度为71.4%，而血清PSA的灵敏度和特异度分别为81.6%和37.1%。结论：前列腺癌患者血清中的NTx和BSP含量对骨转移的发生具有重要的预测意义。

Objective: To study the clinical significance of serum pyridinoline cross-linked N-telopeptides of type I collagen (NTx), serum bone sialoprotein (BSP) and serum prostate specific antigen (PSA) in diagnosing bone metastasis of prostate cancer. Methods: 73 patients were divided into 2 groups: bone metastasis group (n=38) and non-bone metastasis group(,n= 35). The levels of serum NTx, serum BSP and serum PSA were detected by ELISA. Results: The levels of serum NTx and serum BSP in patients with bone metastasis were 25.38±11.13 nmol/l and 46.28±15.29 ng/ml respectively,which was significantly higher than in those without bone metastasis (12.41±7.04 nmol/l and 26.95±14.49 ng/ml respectively) ( P < 0.05) , There were no significant differences in serum PSA of the two groups (128.46±28.67 ng/ml and 105.23±20.04 ng/ml respectively P >0.05). The sensitivity and specificity of serum NTx in the diagnosis of bone metastasis were 90.0% and 68.6% , respectively; the sensitivity and specificity of serum BSP were 84.2% and 71.4%, respectively; the sensitivity and specificity of serum PSA were 81.6% and37.1%. Conclusion: The levels of serum NTx and BSP were important biomarkers for diagnosis of bone metastasis prostate cancer.

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