Objective：To investigate the relationship between glycated albumin levels and early diabetic nephropathy in patients with type 2 diabetes mellitus. Methods：From January 2012 to June 2012，100 patients with type 2 diabetes mellitus in our hospital were enrolled in the study. We used liquid enzymatic to detect glycated albumin，and compare with 100 cases of non- diabetic nephropathy as the control group. Result：Glycated albumin in diabetic nephropathy groups was higher than that in non-diabetic nephropathy group,There were statistically significant differences in glycated albumin among the 2 groups(P<0.05)，Logistic regression showed that glycated albumin was an independent risk factor impacting on the incidence of diabetic nephropathy and the severity of the disease.Conclusion：Glycated albumin was an independent risk factor impacting in patients with T2DM DN，and plays an important role in the pathogenesis of diabetic nephropathy.