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IFN-α治疗慢性乙型肝炎疗效与HBV基因B、C型关系的研究
作者:蒋自卫  
单位:南京市第二医院
关键词:乙型肝炎病毒 基因型 α-干扰素治疗 
分类号:
出版年·卷·期(页码):2013··第三期(0-)
摘要:

【摘要】 目的:研究IFN-α治疗慢性乙型肝炎疗效与HBV基因B、C型与的关系。方法:基因芯片法对HBV基因分型,观察69例慢性乙型肝炎B、C型患者α-干扰素治疗前、后ALT、HBVDNA水平。结果:69例慢性乙型肝炎患者中B、C型分别是36和33例。干扰素治疗1年时,B型完全应答率(53.35%)高于C型(32.56%),差异有统计学意义(P<0.05)。结论:干扰素治疗慢性乙型肝炎患者B基因型优于C基因型。HBV基因型的检测对干扰素抗病毒治疗有一定的临床指导意义。

【Abstract】Objective: To study the relationship between therapeutic efficacy of treating chronic hepatitis B of IFN-α and HBV genotype B, C . Methods: gene chip method for HBV genotyping, observation ALT, HBVDNA level of 69 cases of chronic hepatitis B patients with type B, C before and after α-interferon treatment. Results: 69 cases of patients with chronic hepatitis B in genotype B, C were respectly 36 and 33 cases. Interferon therapy for 1 years, genotype B complete response rate (53.35%) higher than that of genotype C (32.56%), the difference was statistically significant (P<0.05). Conclusions: interferon therapy in chronic hepatitis B patients with genotype B better than genotype C. The detection of HBV genotype and interferon antiviral therapy has certain clinical significance.

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