【Abstract】Objective: To study the relationship between therapeutic efficacy of treating chronic hepatitis B of IFN-α and HBV genotype B, C . Methods: gene chip method for HBV genotyping, observation ALT, HBVDNA level of 69 cases of chronic hepatitis B patients with type B, C before and after α-interferon treatment. Results: 69 cases of patients with chronic hepatitis B in genotype B, C were respectly 36 and 33 cases. Interferon therapy for 1 years, genotype B complete response rate (53.35%) higher than that of genotype C (32.56%), the difference was statistically significant (P<0.05). Conclusions: interferon therapy in chronic hepatitis B patients with genotype B better than genotype C. The detection of HBV genotype and interferon antiviral therapy has certain clinical significance. |