乳腺浸润性导管癌不同部位的微淋巴管密度与VEGF-C 、D表达的关系-现代医学

乳腺浸润性导管癌不同部位的微淋巴管密度与VEGF-C 、D表达的关系

作者：雷海

单位：四川德阳市人民医院

分类号：

出版年·卷·期（页码）：2013··第三期（0-）

摘要：

目的：探讨乳腺浸润性导管癌中VEGF-C、D的表达及其与不同部位的淋巴管生成关系。方法：通过对79例乳腺浸润性导管癌组织行链霉素-生物素过氧化酶(SP)染色法染色，观察癌肿组织和正常乳腺组织的VEGF-C、D蛋白表达以及D2．40标记的微淋巴管，并分析其相互关系。结果： VEGF-C各组间(-组，+组，++组，+++组) LSD法分析：癌边缘区LMVD在各组间有统计学差异（P<0.05）。Spearman相关分析VEGF-C的表达与癌边缘区LMVD之间成正相关（r=0.721, P=6.44× 10-14，P <0.01）。VEGF-D各组间(-组，+组，++组，+++组，++++组) LSD法分析：癌边缘区LMVD在各组间有统计学差异（P<0.05）。Spearman相关分析VEGF-D的表达与癌边缘区LMVD之间成正相关（r=0.828, P=4.50×10-21，P <0.01）。结论： VEGF-C、D蛋白表达与乳腺癌边缘区LMVD呈正相关，VEGF-C、D促进乳腺癌边缘区LMVD增高具有叠加效应。

Objective: To explore the relationship between the expression of VEGF-C、D and LMVD of different area in invasive ductal breast carcinoma. Methods: Staining by the streptavidin - biotin peroxidase (SP), VEGF-C、D protein and micro-lymphatic marked by D2.40 were expressed from the tissue around tumor , the central breast tumor tissue and normal breast from 79 cases of breast cancer, and analysed the relationship between them. Results: Each group compared with pairwise analysis (VEGF-C：- group，+ group，++ group，+++ group) from LMVD around cancer (LSD method): among every group P<0.05. Positive correlation between VEGF-C and LMVD（r=0.721, P=6.44×10-14，P <0.01）according to Spearman analysis. Each group compared with pairwise analysis (VEGF-D：- group，+ group，++ group，+++ group，++++ group) from LMVD around cancer (LSD method): among every group (P<0.05). Positive correlation between VEGF-D and LMVD（r=0.828, P=4.50×10-21，P <0.01） according to Spearman analysis. Conclusion: VEGF-C、D were positively correlated with LMVD around breast cancer . Having superimposed effect the VEGF-C、D increased the LMVD around breast cancer .

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