Department of Gastroenterology, Xiang Shui Xian people's hospital 224600,jiangsu [Abstract] Objective: To investigate the SSTR subtypes expression and distribution in tissues of colorectal carcinoma and relationship with their clinicopathological feature . Methods: The total 41 cases of colorectal carcinoma tissues and their adjacent tissues(23cases) were involved in this study at random. The expression of SSTR1～3 subtype proteins in 41 cases of the colorectal carcinoma tissues were detected by immunohistochemistry used by two-step way. the expressions of SSTR1～3 subtype proteins and clinical pathology were analyzed with Fisher’s exact probabilities method and spearman’s non-parametric analysis. Results The expression levels of SSTR1～3 subtype proteins in the colorectal carcinoma tissues were 65.8% (27/41)、60.9%(25/41) and 56.1%(23/41) respectively, which shows that the expressions of SSTR1～3 subtype proteins were significantly lower than that in adjacent normal colorectal carcinoma tissues（p<0.05）.It also shows that the expressions of SSTR1～3 subtype proteins were not correlated with gender, TNM staging and metastasis, and the expression of SSTR1 in high differentiated tissues was significantly higher than poorly differentiated tissues. Conclusion SSTR1 subtype protein is the mainly expression pattern in colorectal carcinoma and it may be closely related with development and genesis of colorectal carcinoma, and it inhibites the proliferation of colorectal carcinoma. [KEY WORDS] Colorectal carcinoma； Somatostatin； somatostatin receptor； Immunohistochemistry