亚临床甲状腺功能异常与血清NT-pro-BNP水平相关性的研究-现代医学

亚临床甲状腺功能异常与血清NT-pro-BNP水平相关性的研究

单位：沈阳市第五人民医院

分类号：

出版年·卷·期（页码）：2012·40·第六期（635-638）

摘要：

目的研究亚临床甲状腺功能异常不同亚组间血浆中NT-pro-BNP浓度的差异。方法选取2002—2010年内分泌科及心内科住院患者122人，年龄23—82岁,其中男性54例，女性68例，根据血清TSH水平分为A: 亚临床甲减1组（TSH4.5—9.9mU/L）（n=26） B: 亚临床甲减2组（TSH≥10mU/L）（n=30） C: 亚临床甲亢1组（TSH≥0.1，﹤0.45mU/L）（n=24）D: 亚临床甲亢2组（TSH﹤0.1mU/L）（n=21），E:对照组为甲状腺功能正常组TSH(0.45—4.5 mU/L)（n=21），测定血清NT-pro-BNP浓度。结果亚临床甲亢2组（TSH﹤0.1mU/L）血清NT-pro-BNP浓度较对照组增高（95%CI：57.8477-168.5159， P＜0.05），较亚临床甲亢1组（TSH≥0.1，﹤0.45mU/L）显著增高（95%CI：11.5080-138.5656，P＜0.05）. 亚临床甲减1组（TSH4.5—9.9mU/L）和亚临床甲减2组（TSH≥10mU/L）血清NT-pro-BNP浓度较对照组没有明显差异（P＞0.05）。受试者体重指数、空腹血糖水平、左室重量指数与血浆NT-pro-BNP浓度没有相关性。结论亚临床甲亢患者TSH﹤0.1mU/L时，心力衰竭的发生风险明显增加。

Objective to evaluate the serum NT-pro-brain natriuretic peptide in different subgroup of the subclinical thyroid dysfunction. Methods the study included 122 patients to be in hospital in the department of endocrinology and cardiology from the year 2002 to 2010,who,on the basis of plama levels of TSH,were divided intoA: Subclinical hypothyroidism 1（TSH4.5—9.9mU/L）（n=26）B: Subclinical hypothyroidism 2（TSH≥10mU/L）（n=30）C: Subclinical hyperthyroidism 1（TSH≥0.1，﹤0.45mU/L）（n=24）D: Subclinical hyperthyroidism 2（TSH﹤0.1mU/L）（n=21）E:control subjects with normal thyroid profile TSH(0.45—4.5 mU/L)（n=21）,to evaluate the serum NT-pro-brain natriuretic peptide. Result compared to control subjects, Subclinical hyperthyroidism were characterized by higher serum NT-pro-brain natriuretic peptide ,this increase was particularly pronounced in Subclinical hyperthyroidism 2（TSH﹤0.1mU/L）compared to Subclinical hyperthyroidism 1（TSH≥0.1，﹤0.45mU/L）, serum NT-pro-brain natriuretic peptide did not differ between patients in Subclinical hypothyroidism,nerither 1（TSH4.5—9.9mU/L）nor 2（TSH≥10mU/L）,there is no associativity of the serum NT-pro-brain natriuretic peptide in different BMI index,blood-fasting sugarand ventriculus sinister weight index . Conclusions the risk of heart failure is increased when TSH﹤0.1mU/L in Subclinical hyperthyroidism.

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