Objective To define the ideal time occasion for intubation after rocuronium administration during target-controlled infusion (TCI) of propofol and remifentanil. Methods sixty consenting ASA Ⅰor Ⅱ patients aged 18～60 years undergoing elective surgery under general anesthesia were randomly divided into 4 groups (n=15 each) according to the intubation time after administration of the muscle relaxant. Anesthesia was induced with propofol and remifentanil and both of them were given by TCI. The target effect site concentration of propofol was set at 3.0～4.0µg/ml and that of remifentanil at 4 ng/ml. A senior anesthesiologist performed the intubations at 1, 1.5, 2 or 3 min after injection of rocuronium. HR, SBP and bispectral index (BIS) were monitored during induction and intubation. The glottic exposure was evaluated with Cormack-Lehane classification and the intubation conditions assessed according to Cooper's score. Results There were no statistically significant differences with the vocal cord conditions (Cormack-Lehane score) in groups T1.5min, T2min and T3min, but the vocal cord conditions at 1.5~3min differed significantly from that at 1 min after rocuronium administration (P<0.05). There were no statistically significant differences in acceptable intubation conditions and the intubation time among the 4 groups. HR and SBP increased significantly after tracheal intubation in all groups (P<0.05), the increase in SBP in group T1min was significantly larger than that in other 3 groups (P<0.05). Conclusion The condition can be more suitable for intubation at 1.5~3 min than that at 1 min after rocuronium administration as the ideal time occasion for intubation during target-controlled infusion (TCI) of propofol and remifentanil.