【Abstract】Objective To assess the clinical effectiveness of application of the vacuum sealing drainage (VSD) in amputation of the patient with critical limb ischemia . Methods The data of 66 amputated patients with critical limb ischemia gangrene were reviewed retrospectively. From January 2005 to Number 2011, of 35 patients ,VSD was applied to treat wound after the limb amputated ，the wound was sutured secondarily after 7 days; From January 2000 to Number 2011, of 31patients , the wound closure was performed at the first-period . The wound healing conditions 、the complication 、the hospital time and cost were evaluated between two groups .Results In the VSD group, the wound healing rate was 91%; the wound infection rate was 0% ;the mortality rate was 9%;the median length of hospital stay was 23.5days ;the median hospital cost was14485yuan ; in the first-period suturing group, the wound healing rate was 52%; the wound infection rate was42 % ;the mortality rate was 19%;the median length of hospital stay was 58.8days ;the median hospital cost was 32213yuan. There was a significant difference between two groups (P<0.01). Conclusion Application of the VSD in amputation of the patient with critical limb ischemia played a positive role in the prevention of wound infection , promoting wound healing ,reducing mortality ,reduction of hospital time and cost etc. It might be adopted widely.