Objective: To explore the characteristics of risk factors and prognosis of acute coronary syndrome (ACS) patients in southern region of Jiangsu Province. Methods: To use Median to access the distribution of risk factors in patients with acute coronary syndrome (ACS) in southern region of Jiangsu Province and to analyze the relationship between the number of risk factors and prognosis. Results: The median of the number of risk factors is 5 in patients with ACS in the Southern region. In the one single risk factor sub-group, the median ratio between the group of age> 65 years, HDL <40mg/dl (male) or <50mg/dl (female) , hypertension, diabetes, triglycerides> 150mg/dl, pre-diabetic and the group of no relative risk factors is 6:5; the median ratio of the sub-group of LDL>70mg/dl is 5:4；the median ratios of the sub-group of male and family history of premature coronary heart disease are respectively 6:4,7:5; the median ratio of the sub-group of smoking, obesity, CRP> 2mg / L is 5:5. The number of risk factors is 2-8 for all patients, with the increase of risk factors numbers, the long-term incidence of MACE increase from 19.3% to 38.6%. Conclusion: In the southern region of Jiangsu Province, risk factors of male and family history of premature coronary heart disease improve the total risk factors numbers, and age > 65 years, HDL <40mg/dl (male) or <50mg/dl (women), hypertension, diabetes, triglycerides> 150mg/dl, pre-diabetes and ect also play important roles. The risk of cardiovascular and cerebrovascular accident increases along with the argument of the number of risk factors.