[Abstract] Objective : To observe the protective effect of Propofol in rats by establishing models of lung ischemia-reperfusion.Methods:Thirty male Sprague-Dawley rats were randomly divided into three groups of ten each: sham group(A) (the left chest was opened without clamping the left hilum of lung),Lung ischemia reperfusion injury group(B)(the injury was induced by clamping the left lung hilum for 45min followed by 120min reperfusion), Propofol group(C)（Propofol＜5mg/kg＞ was injected though femoral vein 30min before clamping left lung hilum, then propofol＜50mg/kg/h＞was injected with the trace pump. Left lung hilum was clamped for 45min and followed by 120min reperfusion）. Group B use the same method to deal with, but inject the same amount of saline; Three groups were given tracheal intubation、mechanical ventilation before opening chest. At the end of the reperfusion,the blood sample was withdrawn from the left ventricals to test the PaO2，the left lung was harvest.We can observe the injury of issue and cell by light microscope,to evaluat pulmonary edema through lung wet-to-dray (W/D) ratio, Malondialdehyde(MDA), Tumor necrosis factor-α(TNF-α)、interleukin-6(IL-6) content and Superoxide dismutase(SOD) activity in lung tissues were measured. Results: The W/D ratio, the lung MDA、TNF-α、IL-6 content in group B and C were significant higher than those in group A,while the PaO2 and SOD activity in group B and C were much lower than those in group A(P<0.05).As compared with group B, The W/D ratio,the lung MDA、TNF-α、IL-6 content in group C were decreased, while the PaO2 and SOD activity in group C were increased notably(P<0.05).Lung histopathology shows: group A slight damage, group B baldly damaged, group C damaged lighter than group B.Conclusion:1、Ischemia reperfusion can make tissue injury seriously.2、Propofol can prevent SD rats lung Ischemia reperfusion injury to some extent by removing oxygen free radicals and inhabiting inflammatory factor.