Objective To analyze the acute coronary syndrome (ACS) in patients with N-terminal brain natriuretic peptide (NT-proBNP) and troponin correlation of NT-proBNP early diagnosis of ACS and risk stratification of clinical significance. Methods Immunoassay analyzers and reagents determination of plasma NT-proBNP in patients with ACS with troponin (cTnI)， compared with acute myocardial infarction (AMI) group， unstable angina (UA) group and control group NT-proBNP concentration changes， analysis of NT-proBNP and cTnI correlation. The results of plasma NT-proBNP. Results AMI group> UA group> control group， P <0.05; grouped according to coronary artery disease， NT-proBNP concentration of 3-vessel disease group than in a disease group， P <0.05; ACS patients with cTnI concentrations NT-proBNP concentrations were positively correlated. Conclusions NT-proBNP levels in patients with ACS can be used for early diagnosis and risk stratification for clinical development of therapeutic intervention strategies may have some clinical reference value.