Ojective: To investigate the safety and efficacy of flurbiprofen for postoperative pain relief in children undergone circumcision. Method: 120 children undergoing circumcision were randomly divided into 4 groups. Group A was control group: 3 ml normal saline was sprayed on the ring cutting wound; Group B was preemptive analgesia group: 5 min before surgery, 1 mg/kg flurbiprofen was slowly intravenous injected and 3 ml normal saline was sprayed on the ring cutting wound at the end of the circumcision; Group C was postoperative analgesia group: 1 mg/kg flurbiprofen was slowly intravenous injected immediately after surgery and 3 ml normal saline was sprayed on the ring cutting wound; Group D was lidocaine group: 3 ml 2% lidocaine was sprayed on the ring cutting wound at the end of the circumcision. Postoperative recovery score, sedation score, pain score, wake-up time, first urination time and side effects were recorded. Results: Recovery score, sedation score, wake-up time and side effects were not differed significantly (P>0.05). Pain score in group B and group C at all time points were significantly lower than those in group A (P< 0.05). Pain score in group B at all time points were significantly lower than those in group C (P<0.05). Compared with group B, pain score in group D at 0.5h and 1h points were not differed significantly(P>0.05), and other time points showed marked differences (P<0.05). Conclusion: Flurbiprofen axetil injection could reduce acute pain in children undergoing circumcision safely, and more effective in preemptive analgesia without marked untoward effect. The local administration of lidocaine could offer short acting analgesia.