脑源性神经营养因子Val66Met基因多态性与强迫症易感性的Meta分析-现代医学

脑源性神经营养因子Val66Met基因多态性与强迫症易感性的Meta分析

单位：江苏省无锡市精神卫生中心

分类号：

出版年·卷·期（页码）：2012·40·第二期（149-154）

摘要：

目的：评价脑源性神经营养因子（BDNF）基因启动子区196位点Val66Met基因（rs6265）多态性与强迫症(OCD)易感性。方法：检索PubMed、EMBASE以及中国生物医学图书馆（CBM）、CNKI数据库（~2011年8月）文献，收集BDNF Val66Met基因多态性与强迫症易感性的病例对照研究，应用RevMan5.1和STATA 11.0对效应量OR值进行分析。结果：最终有5个研究纳入研究，共计有989名强迫症患者和1528名对照者。总研究人群rs6265基因Val:Met的OR=0.84（95%CI：0.73~0.97，P=0.02），Met/Met:Val/Val基因型的OR=1.56（95%CI：1.07~2.27，P=0.02），Met/Met:Val/Val+Val/Met的OR=1.48（95%CI：1.04~2.10，P=0.03）。结论：本Meta分析显示，rs6265 Met/Met基因型及Met等位基因与强迫症遗传易感性相关，携带Met等位基因的患者罹患强迫症的风险增加。但因纳入文献偏少，尚需更多高质量的相关研究对此进一步确认

Objective： To evaluate the association between BDNF Val66Met polymorphism(rs6265) and obsessive compulsive disordor(OCD) susceptibility. Methods： Published work about BDNF Val66Met and OCD from PubMed, EMBASE in English and from CBM, CNKI in Chinese were searched for relevant articles published by the end of August, 2011. The effect size was analysised in RevMan 5.1 and STATA 11.0. Results： A total of 989 OCD patients and 1528 controls from 5 studies were identified. When all groups were pooled, allele contrast(Val:Met and Met/Met:Val/Val and Met/Met:Val/Val+Val/Met) genotype of BDNF Val66Met polymorphism produced significant results, with the OR values were 0.84(95%CI：0.73~0.97，P=0.02) and 1.56(95%CI：1.07~2.27，P=0.02) and 1.48(95%CI：1.04~2.10，P=0.03) respectively. Conclusions： This meta-analysis demonstrates that rs6265 Met allele and Met/Met genotype were associated with a statistically significant increased risk of OCD. Larger additional studies possibly investigating the interaction with other genes and environmental exposures are required to confirm these results.

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