Objective To explore the CT imaging characteristic diagnosis of diffuse axonal injury. Methods 6 cases of diffuse axonal injury that had Multi-slice spiral CT examination within 24h after trauma were retrospectively analyzed. Results 5 cases had patchy intracerebral high-density hemorrhage.1 case had patchy intracerebral low-density shadows.No obvious displacement of median line was showed.5 cases had intracerebral hemorrhage at gray-white mater interface.3 cases had intracerebral hemorrhage at brain stem.3 cases had intracerebral hemorrhage at white mater.2 cases intracerebral hemorrhage corpus callosum.3 cases had interventricular hemorrhage.2 cases had subarachnoid hemorrhage.1 case had patchy intracerebral low-density shadows in frontal lobe and temporal lobe.1 case had cerebral swelling.6 cases also had skull fracture,scalp hematoma,fluid accumulation in sinus or pulmonary trauma. Conclusion. Cases of diffuse axonal injury have serious degree of injury.CT is the preferred method of the emergency examination.CT is able to provide important information for diagnosis of diffuse axonal injury.