Objective To observe the effect of proteasome inhibitor MG132 combined with cisplatin on the xenografts of Hela cells on the nude mice . Methods 1. We inoculated the cells on the nude mice by hypodermic injection under the sterile condition. Nude mice were into divided four stochastic groups. There were 5 mice in every group and managed by the way there in after.(1)control group: 0.2m1 0.9% saline, i.p, (2)MG132 group: MG132 5mg/kg, 0.2m1, i.p, (3)cisplatin group: cisplatin 3mg/kg, 0.2m1, i.p, (4)cisplatin with MG132 group: MG132 5mg/kg, 0.2m1 and cisplatin 3mg/kg, 0.2m1, i.p. 2. Inspection of xenograft's growth, volume and weight. Inspection of pathology and histology: some of xenografts were fixed by 10% formaldehyde. Then they were dehydrated and embed. After slicing up and HE staining. they were observed by light microscope. Results 1. The analysis of variance was used to examine the differences between the four groups on the volume and the weight of the xenografts on the nude mice. The differences reached the statistical significance(p<0.05). 2. Comparing with the control group, the tumor inhibiting rates of MG132 group, cisplatin group and the MG132 with cisplatin group were 15%,48%, 81%; the inhibiting rates of the weight of the xenografts were 9%, 43%, 69% respectively. Conclusion 1. MG132 can inhibit the xenografts of Hela cells on the nude mice and can increase the inhibition effect of cisplatin to them.