To study in elderly patients with lacunar infarction and risk factors of pulmonary infection factors. Methods From January 2001 to January 2011 were treated lacunar infarction in elderly patients with pulmonary infection in 58 cases, and not simply the same period were randomly selected elderly pulmonary infection in 47 patients with lacunar infarction on The clinical data were retrospectively analyzed. Results There were 29factors in the univariate analysis showed that, among them, 10kinds of factors were significant differences, these factors are: age, type 2 diabetes, disturbance of consciousness, bulbar paralysis, endotracheal intubation, tracheal incision, application of breathing machines, oxygen saturation, carbon dioxide partial pressure, serum albumin, immunoglobulin IgG, β2 microglobulin, D dimer in the univariate analysis statistically significant differences in factors of 15 Logistic regression analysis showed: age, type 2 diabetes, serum albumin, β2 microglobulin, D dimmer in patients with lacunar infarction pulmonary infection were independent risk factors. Conclusion The good control of blood sugar, increased serum albumin levels, reduce the β2 microglobulin, lower D dimmer in the prevention of pulmonary patients with lacunar infarction infection have a higher clinical significance.