[Abstract] Objective To explore the effects of applying the mode of rescuing and caring process in the early stage for patients with severe organophosphorus pesticide poisoning．Method According to the time sequence,136 patients with severe organophosphorus pesticide poisoning were divided into the control group (67 cases) and the observation group(69 cases)．The control group were rescued and cared conventionally, the observation group were adopted the mode of rescuing and caring process，and then compared the successful rate of rescuing ．Result The early stage of rescuing successful rate of observation group was 93.8%,the control group was 80%，There was a statistical difference between the two groups(P<0．O5)．Conclusion The mode of rescuing and caring process can improve the level of first aid and reduce the mortality of patients with severe organophosphorus pesticide poisoning.