Objective:To evaluate the clinical efficacy and adverse reaction of metronomic chemotherapy with capecitabine and celecoxib in the treatment of colorectal cancer. Methods:51 patients with colorectal cancer were given with metronomic chemotherapy with capecitabine and celecoxib. Capecitabine and celecoxib was administered orally at a dose of 500mg twice a day and 400mg twice a day respectively.The therapeutic regimen was repeated every 4 weeks.All patients received at least two cycles.The median number of therapeutic cycles was 4.8.Results: of the 51 patients ,no patient achieved complete remission,9 patients achieved partial remission(17.6%),19 patients maintained a stable disease(37.3%).The disease control rate was 54.9%（28/51）.The median time to progression was 5.1months and the median overall survival was 8.4months.Myelosuppression, gastrointestinal and hand-foot syndrome wre the most common toxicities.Conclusion: Metronomic chemotherapy with capecitabine and celecoxib is well effective in controlling the progression of colorectal cancer.Drug-related toxicities are tolerable.