不同血液净化方式对伴急性肾衰的多器官功能障碍疗效的研究-现代医学

不同血液净化方式对伴急性肾衰的多器官功能障碍疗效的研究

单位：广东药学院附属第一医院

分类号：

出版年·卷·期（页码）：2011·39·第二期（178-180）

摘要：

目的：观察血液灌流（HP）联合持续性静脉-静脉血液滤过（CVVH）治疗伴急性肾功能衰竭（ARF）的多器官功能障碍综合征（MODS）患者的临床疗效，并探讨其机制。方法：将40例患者随机分为两组，一组单纯以CVVH治疗，另一组以HP+CVVH治疗，比较两组治疗前后APACHEⅡ评分改善、尿素氮、肌酐和TNF-α及IL-6变化情况。结果：两组治疗后，患者临床状况改善；APACHEII评分均下降，联合治疗组下降更明显；尿素氮和肌酐均下降，两组之间无差别；血清TNF-α及IL-6均降低，但联合治疗组明显优于单纯治疗组(P < 0. 05)。结论：血液灌流联合持续性静脉-静脉血液滤过治疗伴ARF的MODS 可有效调整炎症因子水平，提高患者的治疗效果。

Objective: To investigate the efficacy of heomoperfusion (HP) with continuous blood purification (CBP) on patients suffered from multiple organs failure with acute renal failure and its mechanism. Methods: 40 patients were divided into two groups randomly, one group was received continuous blood purification treatment only, and the other group was received HP with CBP treatment. Compare the change of APACHEⅡscore and the level of BUN, Cr, TNF-αand IL-6 before and after treatment. Results: After treatment, the clinical symptoms of patients in both two groups were improved, the APACHEⅡscore reduced, as well as the level of BUN and Cr. But there was no significance difference of BUN and Cr in two groups. Furthermore, the levels of TNF-αand IL-6 also declined. The efficacy in the combination treatment group was better than the CBP group (P < 0. 05). Conclusion: The treatment of HP with CBP was effective in changing the level of inflammatory and improving patient’s treatment’s effect.

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