联合检测生化标志物在急性心肌梗死中的诊断价值-现代医学

联合检测生化标志物在急性心肌梗死中的诊断价值

单位：广东省深圳市第二人民医院检验科

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出版年·卷·期（页码）：2010·38·第二期（172-174）

摘要：

【摘要】目的探讨生化标志物：缺血修饰白蛋白（IMA）肌红蛋白（Mb）肌酸激酶同工酶（CK-MB）肌钙蛋白I（CTnI）的联合检测对急性心肌梗死（AMI）的早期诊断价值。方法选择因急性胸痛就诊患者120例于即刻、3h、6h、9h、24h连续测定IMA、Mb、CK-MB、CTnI四项指标，观察其变化规律。结果有典型心肌梗死心电图变化组入院即刻IMA、Mb、CK-MB、CTnI敏感性分别为85.7%、38.7%、29.0%、16.1%。IMA敏感性与其他三项相比差别均有统计学意义（P<0.05），在胸痛≤3h时，IMA、Mb、CK-MB、CTnI四项指标联合检测敏感性为95.3%，均高于单项检测，差异有统计学意义（P<0.05）。结论在AMI的早期，IMA是一个比较灵敏的指标，IMA、Mb、CK-MB、CTnI四项指标联合检测诊断AMI明显提高了灵敏度，有较高的临床实用价值。

【Abstract】 Objective To investigate the early diagnostic of combined detection value of biochemical markers including ischemia modified album (IMA)、myohemoglobin(Mb)、creatine kinase isozyme(CK-MB)and cardiac tropnin I(CTnI) in AMI.Methods 120 patients with acute chest pain were enrolled in the investigation .4 biochemical markers (IMA、Mb、CK-MB、CTnI)were monitored continually at diffdrent time points (immediately、3、6、9、24h after chest pain onset).The law of the parameters dymastic changes was investigated in the course.Results In the group of typical varying electrocardiograph ,the sensitivity was 85.7% for IMA,38.7% for Mb,29.0%for CK-MB ,16.0% for CTnI at immediately time point.Its sensitivity of IMA was remarkable different from the other three groups（P<0.05）.The sensitivity of combined detection of IMA、Mb、CK-MB、CTnI was 95.3%,much higher than any single detection at 3h time point（P<0.05）.Conclusion IMA is an early and sensitive marker for AMI.Combined detection of IMA、Mb、CK-MB and CTnI signficantly enhances sensitivity and has a high practical clinical value.

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