美沙拉嗪联合昆明山海棠治疗溃疡性结肠炎临床疗效观察-现代医学

美沙拉嗪联合昆明山海棠治疗溃疡性结肠炎临床疗效观察

单位：湖北省荆门市第一医院

分类号：

出版年·卷·期（页码）：2011·39·第一期（79-81）

摘要：

目的：观察美沙拉嗪联合昆明山海棠治疗溃疡性结肠炎的临床疗效。方法：选择 40例中重度溃疡性结肠炎患者，随机分为两组：A组为对照组20例，美沙拉嗪，4g/d，每日四次口服；B组为实验组20例，美沙拉嗪，4g/d，每日四次口服，昆明山海棠 0.9g/d，每日三次口服。疗程均为 8 周，观察其疗效及不良反应。结果：治疗8周末实验组的总体疗效评价其显效率为 85 %，对照组总体疗效评价其显效率为 65 %，其疗效与实验组相比有差异有统计学意义(P <0.05) 。实验组不良反应发生率为 30%，对照组不良反应发生率为 25 %，无明显统计学意义(P >0.05) 。结论：在中重度溃疡性结肠炎治疗中，沙拉嗪联合昆明山海棠临床疗效要优于单用美沙拉嗪,完全缓解率高，且远期疗效较好。

Objective: To evaluate the curative effect of ulcerative colitis treated by mesalazine combined with Tripterygium hypoglaucum Hutchins. Methods: 40 patients with moderate and severe ulcerative colitis were divided into 2 groups randomly. A group is control group,20 patients, mesalazine was given orally as 4g/d, four times a day; B group is experimental group, 20 patients, mesalazine was given orally as 4g/d, four times a day, combined with Tripterygium hypoglaucum Hutchins given orally as 0.9g/d, three times a day for 8 weeks.Results: The remission rates of experimental group and control group were 85 % and 65 % respectively. The difference was significant (P < 0.05) . There is no marked difference on bad raction between both groups(P >0.05).Conclusion:the effect of mesalazine combined with Tripterygium hypoglaucum Hutchins was higher than that of mesalazine alone for the patients with moderate and severe ulcerative colitis and long- term therapeutic effect was very good.

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