Objective:To explore the expression and clinical significance of H2S in peripheral blood of patients with acute myocardial infarction(AMI).Methods: The research subjects were selected from January 2016 to January 2018 at the Hai'an Hospital Affiliated to Nantong University, 58 patients with acute myocardial infarction were selected as the AMI group, 28 patients with stable angina pectoris(SAP) were selected as the SAP group. At the same time, 30 healthy patients were selected as the control group. The level of H2S in peripheral blood was detected by ELISA. ROC curve was used to evaluate the value of H2S in the diagnosis and prediction of major adverse cardiovascular events(MACE) in acute myocardial infarction. Cox univariate and multivariate regression analysis were used to analyze the relevant factors affecting the prognosis of patients with acute myocardial infarction. Results:Peripheral blood H2S and cTnI in AMI group were significantly higher than those in SAP group and control group, the difference was statistically significant (P<0.05); The area under the ROC curve(AUC) of cTnI and H2S when diagnosing AMI was 0.877 and 0.805, respectively; the combined test AUC was 0.918, which was higher than that of the single test. The sensitivity of cTnI was 78.7% and the sensitivity of H2S was 66.5% in the single test; the combined detection and diagnosis of AMI had an AUC of 0.918 and the sensitivity increased to 90.6%; The AUC of peripheral blood H2S predicted MACEwas 0.797, sensitivity was 82.2%, specificity was 84.6%; The incidence of MACE in the high H2S group was significantly higher than that in the low H2S group (χ2=7.803, P=0.005); Cox multivariate regression analysis showed that LVEF and H2S were closely related to the prognosis of patients with AMI.Conclusion: The expression level of H2S in peripheral blood of patients with acute myocardial infarction can be used as a new biomarker for diagnosis and prognosis of AMI.
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