NSE、GFAP、ADM在热性惊厥患儿血清中变化与神经功能损伤的关系-现代医学

NSE、GFAP、ADM在热性惊厥患儿血清中变化与神经功能损伤的关系

单位：河北医科大学附属河北省儿童医院急诊科, 河北石家庄 050031

分类号：R720.597

出版年·卷·期（页码）：2020·39·第四期（452-455）

摘要：

目的：探讨热性惊厥患儿血清神经元特异性烯醇化酶（NSE）、胶原酸性纤维蛋白（GFAP）、肾上腺髓质素（ADM）的变化及其与患儿神经功能损伤的关系。方法：选取我院诊治的148例热性惊厥患儿（惊厥组）和90例发热未产生惊厥的患儿（非惊厥组），检测对比两组的血清NSE、GFAP、ADM水平，根据患儿动态脑电图结果、不同发作类型将惊厥组进行分层对比血清NSE、GFAP、ADM水平。结果：惊厥组患儿血清NSE、GFAP、ADM水平显著高于非惊厥组；复杂性热性惊厥患儿血清NSE、GFAP、ADM水平显著高于单纯性热性惊厥患儿；经动态脑电图检查，发现62例患儿脑电图异常，86例患儿脑电图正常；脑电图异常患儿血清NSE、GFAP、ADM水平显著高于脑电图正常组患儿，差异具有统计学意义（P<0.05）；治疗3 d后，惊厥组患儿血清NSE、GFAP、ADM水平均较治疗前降低且差异具有统计学意义（P<0.05）。结论：热性惊厥患儿血清NSE、GFAP、ADM水平升高，尤其是出现神经功能损伤的患儿，检测上述指标对于判断热性惊厥是否造成患儿神经功能损伤具有一定的参考作用。

Objective: To investigate the relationship between the changes of serum neuron specific enolase(NSE), glial fibrillary acidic protein(GFAP) and adrenomedullin(ADM) and neurological impairment in children with febrile convulsions. Methods: 148 cases of febrile convulsions (convulsions group) and 90 cases of febrile children without convulsions (non-convulsions group) in our hospital were selected. Serum NSE, GFAP and ADM levels were compared between the two groups, and the seizure groups were stratified and compared with the levels of serum NSE, GFAP and ADM according to the dynamic electroencephalogram(EEG) results and different convulsiontypes.Results: The serum NSE, GFAP and ADM levels of children in the convulsions group were significantly higher than those in the non-convulsions group; The serum NSE, GFAP and ADM levels of children with complex febrile convulsions were significantly higher than those with simple febrile convulsions; Through dynamic electroencephalogram examination, it was found that 62 children had abnormal EEG, and 86 children had normal EEG; serum NSE, GFAP, ADM levels in children with abnormal EEG were significantly higher than those in normal EEG (P<0.05); After 3 days of treatment, the levels of serum NSE, GFAP and ADM in the convulsions group were lower than before treatment and the difference was statistically significant (P<0.05).Conclusion: Serum NSE, GFAP, and ADM levels are elevated in children with febrile convulsions, especially in children with neurological damage. The detection of these indicators has a certain reference for judging whether febrile convulsionscause neurological impairment in children.

参考文献：

[1] 徐健,孙明强,王媛媛,等.热性惊厥患儿血清中表观遗传标志物的表达及临床意义[J].中国现代医学杂志,2017,27(16):35-39.
[2] FAYYAZI A,KHAIEH A,BAGHBANI A.Comparison of effectiveness of topiramate and diazepam in preventing risk of recurrent febrile seizure in children under age of 2 years[J].Iran J Child Neurol,2018,12(3):69-77.
[3] 张应金,梁凤潇,黄润忠,等.S100B蛋白、胶质纤维酸性蛋白和神经元特异性烯醇化酶在早产儿脑损伤中的意义[J].中国小儿急救医学,2017,24(4):309-311.
[4] MYERS KA,SCHEFFER IE,BERKOVIC SF,et al.Genetic literacy series:genetic epilepsy with febrile seizures plus[J].Epileptic Disord,2018,20(4):232-233.
[5] 马裕斌,任广立,罗招云,等.血清神经元特异性烯醇化酶缺血修饰蛋白与新生儿缺氧缺血性脑病严重程度的相关性分析[J].安徽医学,2017,38(11):1432-1435.
[6] 王艳.高热惊厥患儿血清及脑脊液NSE的测定及其意义[J].中外医疗,2018,37(23):188-189,192.
[7] HALLBERG H,RAFNSDOTTIR S,SELVAGGI G,et al.Benefits and risks with acellular dermal matrix (ADM) and mesh support in immediate breast reconstruction:a systematic review and meta-analysis[J].J Plast Surg Hand Surg,2018,52(3):1-18.
[8] 刘其爱，朱文娟，莫炜明，等.联合检测GFAP、 NSE、 hs-CRP对新生儿脑损伤的临床应用评价[J].广东医学,2018，39(11):1650-1653.
[9] 弓高云，刘芬，李金荣.动态脑电图联合NSE检测对复杂性与单纯性热性惊厥患儿的鉴别诊断价值[J].安徽医学，2018(4):453-455.

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