Objective: To study the correlation between serum PCT, inflammatory factors and APACHE Ⅱ, SOFA scores in patients with sepsis. Methods: A total of 125 patients with sepsis treated in our hospital from December 2016 to January 2018 were selected as our objects. According to the examination results, they were divided into sepsis group(40 cases), severe sepsis group (45 cases), septic shock group (40 cases); another 50 cases of healthy physical examination were as control group. The PCT and inflammatory factors, APACHE Ⅱ, SOFA scores of the four groups were compared, and the correlation analysis of PCT and inflammatory factors with Apache Ⅱ and SOFA scores was performed. Results: PCT, IL-6, TNF-α and CRP in the sepsis group, the severe sepsis group and the septic shock group after treatment were significantly higher than those in the control group; PCT, IL-6, TNF-α and CRP in the sepsis group were significantly lower than those in the severe sepsis group and the septic shock group; PCT, IL-6, TNF-α and CRP in the severe sepsis group were significantly lower than those in the septic shock group (P<0.05). APACHCE Ⅱ and SOFA scores in the septic shock group were significantly higher than those in the sepsis and severe sepsis groups; APACHCE Ⅱ and SOFA scores in the severe sepsis group were significantly higher than those in the sepsis group. The differences were statistically significant (P<0.05). PCT was positively correlated with APACHE Ⅱ and SOFA scores (P<0.05); IL-6 was positively correlated with APACHE Ⅱ and SOFA scores (P<0.05); TNF-α and CRP were positively correlated with APACHEII scores (P<0.05). However, TNF-α and CRP were not correlated with SOFA scores (P>0.05). Conclusion: Serum PCT and IL-6 have a good correlation with APACHE Ⅱ and SOFA scores, which can better reflect the severity and prognosis of patients with sepsis. |
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