Objective: To explore the effect of benidipine on blood pressure circadian rhythm, blood pressure variability and cardiac structure in patients with early morning hypertension.Methods: 142 patients with essential hypertension who were admitted to the Department of Cardiology from July 2015 to July 2016 were randomly divided into benidipine group and amlodipine group according to a random number table, 71 cases in each. 24 hours ambulatory blood pressure was measured before and 2 months after treatment with a portable ambulatory blood pressure monitor; after 6 months, the interventricular septal thickness (IVST), left ventricular posterior wall thickness (PWT), and left ventricular inner diameter(LVID) were measured by ultrasound. LVID value and left ventricular mass index (LVMI) were also calculated. Results: The blood pressure of both groups after treatment was significantly lower than thatbefore treatment (P<0.05), but there was no significant difference in blood pressure between the two groups after treatment (P>0.05). After 2 months of treatment, the standard deviation of blood pressure in both groups was significantly lower than that before treatment (P<0.05). However, there was no significant difference in standard deviation of mean blood pressure, nighttime blood pressure, and 24-hour mean blood pressure between the two groups after treatment (P>0.05), while the mean blood pressure standard deviation of the benidipine group was significantly lower than that of the amlodipine group (P<0.05). There were no significant changes in IVST, PWT, and LVMI before and after treatment between the two groups (P>0.05). There was no significant difference in IVST, PWT and LVMI between the two groups after treatment (P>0.05).Conclusion: Benridipine and amlodipine can reduce blood pressure, nighttime and daytime blood pressure in patients with early morning hypertension, reduce blood pressure variability, without increasing the degree of left ventricular hypertrophy. Benedipine is superior to amlodipine in reducing variability of early morning systolic blood pressure. |
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