Objective: To detect the mutations of prothrombin (PT) gene G20210A and coagulation factor Ⅴ (FⅤ) gene Leiden in patients with central retinal vein occlusion (CRVO), and explore the relationships between the two mutations with CRVO. Methods: 82 patients with CRVO were selected as study group from June 2016 to December 2018, and 80 healthy people were selected as control group. The serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured by automatic biochemical analyzer; the levels of serum homocysteine (Hcy) and folic acid (FA) were detected by automatic chemiluminescence analyzer; restriction fragment length polymorphisms of PT gene G20210A and FⅤ gene Leiden were detected. Logistic regression was used to analyze the risk factors of CRVO. Results: There was no significant difference in age, gender and alcohol consumption between the study group and the control group (P>0.05). The detection values of Hcy, TC, TG, HDL-C and LDL-C in the study group were significantly higher than those in the control group (P<0.05); the detection value of FA in the study group was significantly lower than that in the control group (P<0.05). Only PT gene G20210A wild type and FⅤ gene Leiden wild type were detected in both study group and control group, and no mutation was found. Logistic analysis showed that FA,TC, TG and LDL-C were all risk factors for CRVO (P<0.05). Conclusion: FA, TC, TG and LDL-C are risk factors for CRVO, Leiden mutation of PT gene G20210A and FⅤ gene is not associated with CRVO. |
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