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人FOXA1蛋白在卵巢上皮癌中的表达及其临床意义
作者:钟慧  刘利英  任晓红  党洁  渠淑云 
单位:陕西省核工业215医院 妇科, 陕西 咸阳 712000
关键词:卵巢上皮癌 叉头盒蛋白A1 预后 
分类号:R737.31
出版年·卷·期(页码):2019·47·第五期(493-498)
摘要:

目的:探讨卵巢上皮癌患者病理组织中叉头盒蛋白A1(FOXA1)表达情况及其对卵巢癌预后的影响。方法:采集2015年1月至2017年11月于本院收治并经病理确诊的163例卵巢上皮癌患者肿瘤组织标本,应用免疫组织化学方法检测病理组织中人FOXA1蛋白表达的情况。应用Log-Rank检验比较低FOXA1蛋白表达患者与高FOXA1蛋白表达患者间的生存时间差异,并应用COX模型探索卵巢上皮癌预后的影响因素。结果:163例患者中FOXA1蛋白处于高表达水平的比例较高(74.85%),并且FOXA1蛋白高度表达比例在不同肿瘤分期、不同肿瘤直径患者间的差异均有统计学意义(P<0.05)。高表达FOXA1蛋白的患者生存时间较低表达FOXA1蛋白的患者生存时间短(P<0.000 1);卵巢上皮癌患者病理组织中FOXA1蛋白高度表达是卵巢癌预后的风险因素(HR=2.24)。结论:FOXA1蛋白表达在卵巢上皮癌的发生、发展中起着重要的作用,并且与患者预后有密切的关系。干预FOXA1的表达可成为延缓或控制卵巢上皮癌发展的可行方法。

Objective:To explore the express of Forkhead box A1(FOXA1) in human epithelial ovarian carcinoma (EOC) and the effects on EOC prognosis. Methods:Immunohistochemical analysis was performed to evaluate FOXA1 expression in 163 epithelial ovarian carcinoma tissue specimens. The present study analyzed the association between FOXA1 expression and clinical characteristics in the patients with EOC. Kaplan-Meier method was used for survival analysis. Results:The immunohistochemical expression of FOXA1 in EOC tissues was associated with the FIGO grade and diameter of tumor. The results of Kaplan-Meier survival curve revealed that high FOXA1 expression was associated with decreased overall survival time in the patients in relation with low FOXA1 expression (P<0.05). Conclusion:FOXA1 is over expressed in EOC and associated with clinicopathological features, including overall survival time. FOXA1 potentially represents a novel biomarker and therapeutic target for EOC.

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