目的：探讨前梯度蛋白2（AGR2）和上皮性钙黏蛋白（E-Cad）在食管癌组织中的表达及其临床意义。方法：采用免疫组化染色检测109例食管癌组织和77例癌旁组织中AGR2和E-Cad的表达，比较AGR2、E-Cad与食管癌患者临床病理参数的关系；Kaplan-Meier检验分析不同AGR2、E-Cad表达与食管癌患者总体生存率的关系。结果：AGR2在食管癌组织中的阳性表达率（73.8%）显著高于癌旁组织的10.4%（P<0.05），E-Cad在食管癌组织中的阳性表达率（21.4%）显著低于癌旁组织的90.9%（P<0.05），食管癌组织中AGR2及E-Cad的表达与肿瘤淋巴结转移、TNM分期相关（均P<0.05）。总体生存率AGR2高表达食管癌患者明显低于低表达患者，E-Cad高表达患者明显高于低表达患者（均P<0.05）；食管癌组织中AGR2的表达与E-Cad表达呈负相关（r=-0.767，P<0.05）。结论：食管癌组织中AGR2、E-Cad表达异常；AGR2高表达和E-Cad低表达可能与肿瘤转移、食管癌不良预后相关。

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