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食管癌组织中前梯度蛋白2和上皮性钙黏蛋白的表达及其临床意义
作者:钱龙  富智  丁辉  黄苏 
单位:南京医科大学附属淮安第一医院 心胸外科, 江苏 淮安 223001
关键词:前梯度蛋白2 上皮性钙黏蛋白 食管癌 表达 淋巴结转移 预后 
分类号:R735.1
出版年·卷·期(页码):2019·47·第四期(406-411)
摘要:

目的:探讨前梯度蛋白2(AGR2)和上皮性钙黏蛋白(E-Cad)在食管癌组织中的表达及其临床意义。方法:采用免疫组化染色检测109例食管癌组织和77例癌旁组织中AGR2和E-Cad的表达,比较AGR2、E-Cad与食管癌患者临床病理参数的关系;Kaplan-Meier检验分析不同AGR2、E-Cad表达与食管癌患者总体生存率的关系。结果:AGR2在食管癌组织中的阳性表达率(73.8%)显著高于癌旁组织的10.4%(P<0.05),E-Cad在食管癌组织中的阳性表达率(21.4%)显著低于癌旁组织的90.9%(P<0.05),食管癌组织中AGR2及E-Cad的表达与肿瘤淋巴结转移、TNM分期相关(均P<0.05)。总体生存率AGR2高表达食管癌患者明显低于低表达患者,E-Cad高表达患者明显高于低表达患者(均P<0.05);食管癌组织中AGR2的表达与E-Cad表达呈负相关(r=-0.767,P<0.05)。结论:食管癌组织中AGR2、E-Cad表达异常;AGR2高表达和E-Cad低表达可能与肿瘤转移、食管癌不良预后相关。

Objective:To explore anterior gradient 2(AGR2) and E-cadherin(E-Cad) expression in esophageal carcinoma tissues and its clinical value for prognosis. Methods:The expression levels of AGR2 and E-Cad in 109 esophageal carcinoma tissues and 77 paracancerous tissues were determined by immunohistochemical staining, and the relationship between the expression of AGR2, E-Cad and the clinicopathological parameters of esophageal cancer patients were compared.The over-all survival rate of the patients was analyzed by Kaplan-Meier method. Results:The expression of AGR2 in esophageal carcinoma tissues(73.8%) was significantly higher than that in paracancerous tissues(10.4%)(P<0.001).The expression of E-Cad in esophageal carcinoma tissues(21.4%)was significantly lower than that in paracancerous tissues(90.9%)(P<0.001).The expression of AGR2 was related to lymph node metastasis and TNM staging(P<0.05).The over-all survival rate in the AGR2 higher expression group was markedly lower than that in the lower expression group,and the over-all survival rate in the higher E-Cad expression group was markedly higher than that in the lower expression group(P<0.05).There was a negative correlation between AGR2 and E-Cad in the esophageal carcinoma tissues(r=-0.767,P<0.05). Conclusion:Aberrant expression of AGR2 and E-Cad in esophageal cancer tissues, the up-regulated of AGR2 and down-regulated of E-Cad are risk factors for tumor metastasis and poor prognosis.

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