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瑞舒伐他汀钙片联合拜阿司匹林治疗颈动脉斑块的效果分析
作者:任静1  赵青2 
单位:1. 新疆医科大学第六附属医院 超声科, 新疆 乌鲁木齐 830000;
2. 新疆维吾尔自治区 中医医院 超声科, 新疆 乌鲁木齐 830000
关键词:瑞舒伐他汀 拜阿司匹林 颈动脉斑块 
分类号:R543.4
出版年·卷·期(页码):2019·47·第四期(377-380)
摘要:

目的:探讨瑞舒伐他汀钙片联合拜阿司匹林治疗颈动脉斑块的效果。方法:将合并有颈动脉斑块的脑血管疾病患者178例分为观察组与对照组各89例,在常规治疗基础上,对照组予拜阿司匹林辅助治疗,观察组予瑞舒伐他汀钙片联合拜阿司匹林辅助治疗,记录两组治疗效果、治疗前后血脂水平及颈动脉斑块变化情况。结果:所有患者都顺利完成治疗,观察组总有效率为94.4%,显著高于对照组的77.5%(P<0.05)。两组治疗后甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均低于治疗前,高密度脂蛋白胆固醇水平高于治疗前(P<0.05);治疗后两组间上述血脂指标差异也有统计学意义(P<0.05)。治疗后观察组的斑块面积低于治疗前及对照组(P<0.05),两组造影剂到达时间差(DAT)显著高于治疗前,增强强度(EI)显著降低(P<0.05);治疗后观察组的DAT、ET较对照组差异也有统计学意义(P<0.05),两组治疗前后斑块达到时间(AT)差异无统计学意义(P>0.05)。结论:瑞舒伐他汀钙片联合拜阿司匹林治疗颈动脉斑块能改善患者的超声造影增强指数,缩小斑块面积,有利于调节血脂水平,从而提高治疗效果。

Objective:To investigate the effects of rosuvastatin calcium tablets combined with aspirin in the treatment of carotid plaque. Methods:One hundred and seventy-eight carotid plaque patients with cerebral vascular disease were randomly divided into observation group and control group with 89 patients in each group. The control group was given aspirin adjuvant treatment, while the observation group received rosuvastatin calcium tablets combined with aspirin treatment. Results:All patients completed the treatment successfully. After treatment, the total effective rates of the observation group and the control group were 94.4% and 77.5%, respectively, and the therapeutic effect in the observation group was significantly better than that in the control group(P<0.05). The levels of triglyceride, total cholesterol and low density lipoprotein cholesterolin the observation group and the control group were all lower than those before treatment, and the levels of high density lipoprotein cholesterolwere higher than those before treatment. There was a statistically significant difference in the lipid indexes between the two groups(P<0.05). After treatment, the plaque area in the observation group was smaller than that before treatment, and it was smaller than that in the control group(P<0.05). The difference of arrival time(DAT) in the observation group and the control group after treatment was more significant than that before treatment, and the enhanced intensity(EI) was decreased(P<0.05) with statistically significant difference(P<0.05). Conclusion:Rosuvastatin calcium tablets combined with aspirin in the treatment of carotid plaque patients can improve the index of contrast-enhanced ultrasound and reduce plaque area, which is conducive to the regulation of serum lipid levels and treatment effect.

参考文献:

[1] LUGINOVA Z,TRIPOTEN M,POGORELOVA O,et al.Effect of short-term intensive rosuvastatin therapy on carotid plaque volume in very high cardiovascular risk patients:a three-dimensional ultrasound imaging study[J].Atherosclerosis,2017,8(263):e40-e41.
[2] 杨慎先,杜长春,李蒙,等.瑞舒伐他汀强化降脂治疗对冠状动脉临界病变斑块结构的影响[J].中国动脉硬化杂志,2015,23(6):594-598.
[3] NATARAJAN P,YOUNG R,STITZIEL N O,et al.Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting[J].Circulation,2017,135(22):2091-2101.
[4] 杨磊,余信国,刘俊超,等.瑞舒伐他汀辅治冠心病介入术后患者的疗效及其对血清IGF-Ⅰ、s E-selectin、TGF-β1水平的影响[J].疑难病杂志,2017,16(1):6-9.
[5] DU R,ZHAO X Q,CAI J,et al.Changes in carotid plaque tissue composition in subjects who continued and discontinued statin therapy[J].J Clin Lipidol,2016,10(3):587-593.
[6] IKDAHL E,ROLLEFSTAD S,HISDAL J,et al.Sustained improvement of arterial stiffness and blood pressure after long-term rosuvastatin treatment in patients with inflammatory joint diseases:results from the RORA-AS study[J].PLoS One,2016,11(4):e0153440.
[7] 石小燕,薛瑞璐,李小琴.瑞舒伐他汀钙治疗冠状动脉弥漫性病变临床效果观察[J].临床研究,2017,25(1):49-50.
[8] IKDAHL E,HISDAL J,ROLLEFSTAD S,et al.Rosuvastatin improves endothelial function in patients with inflammatory joint diseases,longitudinal associations with atherosclerosis and arteriosclerosis:results from the RORA-AS statin intervention study[J].Arthritis Res Ther,2015,8(17):279.
[9] ROLLEFSTAD S,IKDAHL E,HISDAL J,et al.Rosuvastatin-induced carotid plaque regression in patients with inflammatory joint diseases:the rosuvastatin in rheumatoid arthritis,ankylosing spondylitis and other inflammatory joint diseases study[J].Arthritis Rheumatol,2015,67(7):1718-1728.
[10] 娄明,宫海滨,刘奕,等.不同他汀药物短期、大剂量应用对行冠状动脉介入治疗患者肾功能的保护作用[J].中国医药导报,2017,14(29):57-60.
[11] SAPIENZA P,BORRELLI V,STERPETTI A V,et al.Statins reduce levels of metalloproteinases in patients with carotid occlusive disease[J].Int Angiol,2014,33(6):530-539.
[12] 韩燕妮,钟洁愉,董理聪,等.超声造影评价瑞舒伐他汀与阿托伐他汀对颈动脉斑块新生血管的影响[J].临床超声医学杂志,2017,19(6):395-398.
[13] DEGUCHI I,HORIUCHI Y,HAYASHI T,et al.Effects of rosuvastatin on serum lipids and arteriosclerosis in dyslipidemic patients with cerebral infarction[J].J Stroke Cerebrovasc Dis,2014,23(8):2007-2011.
[14] 黄朝霞.瑞舒伐他汀钙片强化降脂在冠心病患者治疗中的作用[J].影像研究与医学应用,2017,1(7):209-210.

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