呼吸窘迫综合征患儿血清HMGB1、IL-6、NGAL的表达水平及临床意义-现代医学

呼吸窘迫综合征患儿血清HMGB1、IL-6、NGAL的表达水平及临床意义

单位：1. 乐陵市人民医院小儿内科, 山东乐陵 253600;
2. 乐陵市人民医院检验科, 山东乐陵 253600

关键词：呼吸窘迫综合征新生儿高迁移率族蛋白B1 白细胞介素-6 中性粒细胞明胶酶相关脂质运载蛋白

分类号：R725.6

出版年·卷·期（页码）：2019·47·第三期（308-312）

摘要：

目的：探讨新生儿呼吸窘迫综合征（NRDS）患儿血清中高迁移率族蛋白B1（HMGB1）、白细胞介素-6（IL-6）、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的表达水平及临床意义，为临床NRDS患儿病情及预后评估提供参考。方法：选取2016年7月至2018年3月本院小儿内科收治的46例NRDS患儿作为观察组，另选同期本院出生的30例健康新生儿作为对照组。观察组患儿根据病情严重程度分为轻度组（n=27）和重度组（n=19），根据预后情况分为生存组（n=30）和死亡组（n=16）。检测并比较观察组和对照组以及观察组不同病情、不同预后的NRDS患儿的血清HMGB1、IL-6、NGAL水平。结果：与对照组比较，观察组新生儿血清HMGB1、IL-6、NGAL水平均明显升高，差异有统计学意义（P<0.05）。与轻度组比较，重度组患儿血清HMGB1、IL-6、NGAL水平均明显升高，差异有统计学意义（P<0.05）。与生存组比较，死亡组患儿血清HMGB1、IL-6、NGAL水平均明显升高，差异有统计学意义（P<0.05）。多因素Logistic回归分析结果表明，HMGB1、IL-6、NGAL水平均与NRDS患儿预后有关（P<0.05）。结论：NRDS患儿血清HMGB1、IL-6、NGAL水平明显升高，且其升高程度与患儿病情、预后密切相关，可作为NRDS患儿病情及预后评估的参考指标。

Objective:To investigate the expression levels and clinical significance of serum high mobility group box protein B1 (HMGB1),interleukin-6 (IL-6) and neutrophil gelatinase associated lipocalin (NGAL) inneonatal respiratory distress syndrome (NRDS),so as to provide reference for clinical NRDS prognosis and prognosis evaluation. Methods:Forty-six children with NRDS in the neonatal intensive care unit (NICU) of our hospital from July 2016 to March 2018 were selected as the observation group,and 30 healthy newborns born in the same period were selected as the control group.The children in the observation group were divided into mild group (n=27) and severe group (n=19) according to their condition,and divided into survival group (n=30) and death group (n=16) according to their prognosis.The levels of serum HMGB1,IL-6 and NGAL were compared between the observation group and the control group,as well as the NRDS newborns with different condition and prognosis.Results:Compared with the control group,the levels of serum HMGB1,IL-6 and NGAL in the observation group were significantly higher,the differences were statistically significant (P<0.05).Compared with the mild group,the serum HMGB1,IL-6 and NGAL levels in the severe group were significantly higher,the differences were statistically significant (P<0.05).Compared with the survival group,the serum levels of HMGB1,IL-6 and NGAL in the death group significantly increased,and the differences were statistically significant (P<0.05).Multivariate Logistic regression analysis showed that the levels of HMGB1,IL-6 and NGAL were all related to the prognosis of NRDS(P<0.05). Conclusion:The serum levels of HMGB1,IL-6 and NGAL in children with NRDS significantly increase,and the degree of the increase is closely related to the condition and prognosis of the children.They can be used as the reference indexes for the condition of children with NRDS and the evaluation of prognosis.

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