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血清总胆汁酸水平与2型糖尿病的关系
作者:梁贝贝  凌宏威  周冬梅  孙娟  应长江  李伟 
单位:徐州医科大学附属医院 内分泌科, 江苏 徐州 221006
关键词:2型糖尿病 总胆汁酸 胰岛素抵抗 甘油三酯 血压 体重指数 
分类号:R587.1
出版年·卷·期(页码):2019·47·第三期(250-254)
摘要:

目的:研究血清总胆汁酸水平与2型糖尿病的相关性。方法:搜集2015年1月至2018年4月在我院就诊或体检者共228例,其中2型糖尿病患者147例作为研究组,同期健康体检者81例作为对照组。所有研究对象均空腹8 h以上,收集其外周静脉血以检测临床观察指标。结果:Mann-Whitney U检验显示研究组的血清总胆汁酸水平显著高于对照组(P<0.001),且差异具有统计学意义。在研究组中总胆汁酸水平与体重指数(BMI)、胰岛素抵抗指数、年龄、收缩压、甘油三酯正相关(P<0.05),在对照组无明显相关性。二元Logistic回归分析表明,总胆汁酸和糖化血红蛋白是2型糖尿病的危险因素。结论:研究组空腹总胆汁酸水平显著升高,且总胆汁酸水平与甘油三酯、胰岛素抵抗指数、血压、BMI显著正相关,提示总胆汁酸与2型糖尿病关系可能涉及到更多的因素。胰岛素抵抗可能是胆汁酸在2型糖尿病中调节糖代谢的新的信号通路,对2型糖尿病机制研究及治疗提供新思路。

Objective:To study the correlation between serum total bile acid and type 2 diabetes. Methods:A total of 228 patients were enrolled in the Affiliated Hospital of Xuzhou Medical University from January 2015 to April 2018, including 147 patients with type 2 diabetes as study group and 81 healthy controls. All subjects should be fasted for more than 8 hours, and their peripheral venous blood was collected to detect clinical research indicators.Results:In this experiment, a significantly higher serum total bile acidlevel in the study group than that in the healthy control group was obtained by the Mann-Whitney U test (P<0.001), and the difference was statistically significant. In the study group, total bile acid and body mass index(BMI), insulin resistance, age, systolic blood pressure, and triglyceride were positively correlated (P<0.05.), and there was no significant correlation in the control group. Binary Logistic regression analysis showed that total bile acid and glycated hemoglobin were risk factors for type 2 diabetes. Conclusion:The total bile acid in the study group was significantly increased, and the total bile acid was positively correlated with triglyceride, insulin resistance, blood pressure and BMI, suggesting that the relationship between total bile acid and type 2 diabetes may involve more factors. Insulin resistance may be a new signaling pathway for bile acids to regulate glucose metabolism in type 2 diabetes, providing new ideas for the study and treatment of type 2 diabetes.

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