孕妇胎盘组织中缺氧诱导因子HIF-1α的表达与子痫前期发病关系的Meta分析-现代医学

孕妇胎盘组织中缺氧诱导因子HIF-1α的表达与子痫前期发病关系的Meta分析

单位：江苏省妇幼保健院

分类号：

出版年·卷·期（页码）：2014·42·第三期（261-264）

摘要：

目的探讨孕妇胎盘缺氧诱导因子（HIF-1α）表达变化与子痫前期发病的关系。方法以“缺氧诱导因子（HIF-1α）、子痫前期（Preeclampsia）”为检索词检索检索Medline、EMBase、PubMed数据库、中国生物医学文献数据库、万方数据库，收集缺氧诱导因子（HIF-1α）与子痫前期发病关系的病例对照研究，筛选、评价文献并提取数据进行Meta分析。结果共纳入6项研究，主要从病例组与对照组方法的选择、病例组与对照组的可比性、接触暴露评估方法3个方面对文献进行评价。Meta分析结果表明，子痫前期组胎盘组织中缺氧诱导因子（HIF-1α）表达水平高于正常妊娠组[OR=5.65, 95%CI(3.42, 9.33)]。结论孕期缺氧诱导因子HIF-1α的高表达与子痫前期的发病有关。

　　 Objecttive To evaluate the relationship between Hypoxia-inducible factor-1ɑ in placenta and preeclampsia. Methods Through the term of Hypoxia-inducible factor-1ɑ and Preeclampsia to searching a case-control study in which some cases about the relationship between Hypoxia-inducible factor-1ɑ in placenta and preeclampsia were searched out from Mesline, EMBase, Pubmed, Google, CBMdisc , wangfang darabase to have the sifted, evaluated and extracted for meta-analysia. Results The author evaluated the six articles being involved in the case-control study finally from three aspects: the selection nethods of case and control group used, comparability of the two groups, contact exposure assessment method. Meta-analysis indicated that there were statistical significance between Hypoxia-inducible factor-1ɑ in placenta and Preeclampsia [OR=5.65, 95%CI(3.42, 9.33)]. Conclusion There is significant correlation between Hypoxia-inducible factor-1ɑ in placenta and development of Preeclampsia.

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